Poison in her original version (the Japanese) is a trans gendered person. It is just insane all the GLBT phobia in the game industry, when in fact some game developers/programmers are transsexuals / transgendered people. Here I am of course, thinking about a woman who has giving quite a lot of information upon Sonic, whom was a MtF trans gendered person. Yes she is still alive, I am just using past tense, to explain that people who are either post op, or pre op who feel they are born in the wrong body should be called what they prefer, which is either women or men depending on which gender they are started out as. So my "short" answer is, Poison is a woman, but that is because she is/was a MtF TS/TG. The LGBT/GLBT community is now calling it gender, instead of sexual. Even though when you used the word transsexual, it meant the same thing. Cause the word "sexual" was not meant as in sexuality, but in the meaning of gender. Yeah I have just written a long ass post, but hey that is life.