Hmmmm, the most fun I've had this gen would probably stem from: Metroid Prime 3: Corruption Bioshock The Orange Box Metal Gear Solid 4: Guns of the Patriots Mass Effect 2 Romping through Wipeout HD Fury atm as well, although i haven't spent too much time with it yet.
I just played through Heavy Rain over the past couple days and have not felt literally THAT vulnerable in a game in a long time. Fantastic experience. Also enjoying Yakuza 3 for nostalgic reasons. All the CAVE ports on 360 have been great too.